![]() ![]() However, one obviously neglects that an individual may experience more than one non-fatal event which leads to a loss of information. Including recurrent events to quantify the treatment effect seems appealing as the information from each patient is fully exhausted. On the other hand, the different event processes are usually rather complex and as a consequence a corresponding effect measure will be a mixture of the treatment’s direct and indirect effects making the interpretation more difficult. Whereas the time to first event approach defines the current standard and is therefore already well understood, the application of recurrent event models to composite endpoints is rather rare. The aim of this work therefore is to evaluate the performance of existing recurrent event models for the specific data situation of a composite endpoint which is commonly characterized by the following properties:įor each event type, recurrent or terminal, there exist separate event processes that might be correlated or not. #DIFFERENT TYPES OF LICENSES IN BMC REMEDY TRIAL#. ![]()
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